Toxicology

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DEPARTMENT OF TOXICOLOGY

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Department Overview

Head of Department: Prof. M.K. Gupta

Toxicology is defined as the study of the adverse effects of chemical, physical or biological agents on people, animals and the environment.  More recently, it has been defined as the science of health safety.  There are a very few Universities that impart education in Toxicology.  A strategically important turning point in India was to initiate toxicology education at Ch Charan Singh University, Meerut in 2004 with the support of University Grants Commission, New Delhi under its Innovative Assistance Program.  It is the only University in India that awards PG degree to students in basic and applied toxicology.  The admission to master’s program in toxicology is open to candidates possessing B.Sc degree with Botany. Chemistry and Zoology., B.Sc in biotechnology or microbiology or biochemistry., B.Pharm., BVSc and MBBS degrees. So farseventeen batches of students have passed out from this department. The Department enrolls students for Ph.D. degree as well.

   The curriculum has been so designed that it includes sixteen courses on basic and applied aspects of toxicology.  Each course consists of lectures, practical exercises, seminars assignments and tests.  Students are encouraged to undergo training at apex institutes of toxicology in the country like Indian Institute of Toxicology Research (IITR), Lucknow., Central Drug Research Institute (CDRI) Lucknow., National Institute of Occupational Health (NIOH), Ahmedabad., reputed pharmaceutical industries and non clinical laboratories.

   The department has committed faculty.  Its founder coordinator Prof S V S Rana, who is an internationally acclaimed toxicologist nurtured this department so well that its students have been able to find a niche in several international centers of repute like Korea Institute Of Toxicology, Daejeon, South Korea., A & M Texas University, Texas (USA)., Griffith University, and Brisbane University of Australia and Harward Medical School, USA.  A couple of students are working at All India Institute of Medical Sciences, New Delhi., National Institute of Pharmaceutical Education and Research, Mohali, IITR, Lucknow ., Sri Ram Institute of Industrial Research, New Delhi and National Forensic Science Laboratory, New Delhi.

   Research contribution:

   Department of Toxicology has made significant contribution in the sub disciplines of biochemical toxicology., free radical biology., toxicity of environmentally significant heavy metals., eco toxicology., occupational toxicology and nanotoxicology. This is the only laboratory in India that practices biological monitoring as an essential tool of human health risk assessment to toxic chemicals in various organized and unorganized occupational environments.  The faculty of the Department has published more than 200 research papers in journals of repute focusing on public health aspects.

International collaboration

   Department signed a MOU in 2020 for five years with Siberian Federal University and State medical university, Krasnoyarsk, Russia. A MOU was also signed with Korea Institute of Toxicology (KIT), South Korea on 29th Feb 2007 to promote collaborative research programs.  Dr. Han, the then President/Director of KIT visited the Department to sign the MOU.  The investigators have established research collaboration with Okayama University Medical School, Okayama, Japan and Pecs University, Hungary.

National collaboration:

  The department has established research collaboration with national institutes of higher learning and research like IITR, Lucknow., NIOH, Ahmedabad., Rallis India, Bengaluru and IVRI,Izatnagar., NIPER, Mohali., INMAS,Delhi and IIT, Kharagpur.

Centre of excellence in Toxicology by UP GOVT

Govt of Uttar Pradesh has identified this Department as Centre of Excellence in Toxicology in 2021.

Latest Updates

Programme/ Courses

The department is currently offering the following programmes of study:

Ph.D. (Toxicology)

Ph.D. (Toxicology)
About Programme:

The department pursues research in the areas of Biochemical Toxicology, Therapeutic/toxicological evaluation of Nanoparticles (using in vivo and in vitro models). The department has excellent research laboratory equipped with sophisticated instruments to carry out researches of an international standard.

Duration:
Number of Seats:
4
Nature/Type:
Eligibility Conditions:

M. Sc. Programme (CBCS)

M. Sc. Programme (CBCS)
About Programme:
Duration:
Number of Seats:
30
Nature/Type:
Eligibility Conditions:

M.Sc NEP (Toxiology)

M.Sc NEP (Toxiology)
About Programme:
Duration:
Number of Seats:
N/A
Nature/Type:
Eligibility Conditions:

Post Graduate Diploma in Public Health (PGD-PH)

Post Graduate Diploma in Public Health (PGD-PH)
About Programme:
Duration:
Number of Seats:
20
Nature/Type:
Eligibility Conditions:

Pre-Ph.D. Coursework Toxiology

Pre-Ph.D. Coursework Toxiology
About Programme:
Duration:
Number of Seats:
N/A
Nature/Type:
Eligibility Conditions:

Faculty

Assistant Professor

Dr. Yashvendra Verma

M.Sc., M.Phil., Ph.D.

No Resume Available

Satyandra Kumar

M.Sc., M.Phil., Ph.D.

No Resume Available

Guest Faculty

Prof. S. V. S. Rana

M.Sc., Ph.D.

No Resume Available

Syllabus

Programme Name Download New/ Revised Syllabus
M. Sc. Programme (CBCS) Toxiology
M. Sc. Toxicology
M.Sc. Toxicology/ B.Sc. in Research/ Honors(2022-23)
Post Graduate Diploma in Public Health (PGD-PH)
Pre-Ph.D. Coursework

Facilities

Biochemical Toxicology

This Facility is well equiped with all necessary scientific instruments. Researchers working on biochemical mechanism of xenobiotics. 

Aquatic Toxicology

Aquatic Toxicology facility is dedicated to toxicity related to aquatic ecosystem. Our main focus is to develop alternative animal models. Presently we are working on Zebra Fish embryo as an alternative animal models to assess the toxic risk Assessment of xenobiotics specially emerging/ newly synthesized pollutatnts viz. nanoparticles, microplastics. We are also working on another wonderful organisms (Biolmuniscent bacteria) to assess chemical risk assessment.

In Vitro Facility

This Facility having all required facility for in vitro study of chemicals/ drugs. This facility is dedicated with cell line study. Presently we are working on Breast cancer cell lines (MCF-7) and Glioblastoma cells (U 87MG)

Toxicologic Histopathology

This facility is dedicated to toxicologic pathology study of various animals. It is equiped with microtome and staining 

Job/Placement

Job/ Placement

Placements

1. Mrs. Jyoti (2017), working in Institute for Industrial Research and Toxicology

2. Misbah Kausar (2018) working in Forensic care, Institute of Forensic Science, New Delhi

3. Moh Suaib (2019) working in Peptech Bioscience, New Delhi

4. Shivam Sharma (2020) Advisor, Torrent Pharma, New Delhi.

5. Deepti Arora (2020) Faculty of BioScience, Brahmanand College, Bulandshahr.

6.Sainky Gautam (2020 Batch) Working as Executive quality Control, Suraksha Pharma, Pvt. Ltd.Roorkee 

7. Shruti Nagar (2020) Working as QA officer quality Control, Fast Pharma, Pvt. Ltd.Roorkee 

8. Tarun Kumar (2022) working in BML Parental Pharmaceuticals, Roorkee.

9. Moh. Saleem (2022) working in Forensic Science Laboratory, Mumbai. 

Research & Publications

RESEARCH PAPERS IN PEER-REVIEWED JOURNALS

S.No. Author Name Inventor's Name Title Name of Journal Month Year of Publication
1 Dr. Satyandra Kumar Impact of Covid-19 Pandemic on Indian Agriculture International Journal of Trade & Commerce 2020-01-01
2 Dr. Yeshvandra Verma Toxicity risk assessment in tobacco chewers, cigarette smokers and alcohol consumers using urinary DNA adduct and exfoliated buccal cells micronuclei as non-invasive biomarkers Toxicologie Analytique et Clinique 2022-08-14
3 Dr. Yeshvandra Verma Selectively Imprinted β-cyclodextrin Polymer for Colorimetric Assay of Lysophosphatidic Acid for Point of Care Detection of Ovarian Cancer Chemistry europe 2022-07-26
4 Dr. Yeshvandra Verma Nephrotoxicity of nickel nano and microparticles in rat- a comparative, time dependent study with special reference to antioxidant defence system. Inorganic and nanometal chemistry 2022-03-15
5 Dr. Yeshvandra Verma Duration of exposure modulates combined effects of arsenic and fluoride on oxidative stress in the liver of rat Journal of Environmental Biology 2022-03-01
6 Dr. Yeshvandra Verma Potential toxicity of nickel nano and microparticles on the reproductive system of female rats—a comparative timedependent study Toxicology and Industrial health 2022-01-03
7 Dr. Yeshvandra Verma Liver and kidney function in rats cotreated with fluoride and arsenic for different time intervals FLUORIDE 2021-11-01
8 Dr. Yeshvandra Verma Attributes of oxidative stress in the reproductive toxicity of nickel oxide nanoparticles in male rats Environmental Science and pollution Research 2021-07-22
9 Dr. Yeshvandra Verma Tumor reversion: a dream or a reality Biomarker Research 2021-05-06
10 Dr. Yeshvandra Verma Hepatotoxicity induced by nickel nano and microparticles in male rat: a comparative study Toxicology and Environmental Health Sciences 2021-04-01
11 Dr. Yeshvandra Verma Chemical Signatures of New Pesticides in the Bovine and Caprine Milk Samples Collected from Western Uttar Pradesh (India) Journal of ecophysiology and occupational health 2021-01-03
12 Dr. Yeshvandra Verma Possible mechanisms of liver injury induced by cadmium sulfide nanoparticles in rat Biological trace element research 2021-01-01
13 Dr. Yeshvandra Verma Assessment of cadmium sulphide nanoparticles toxicity in the gills of a fresh water fish Environmental Nanotechnology, Monitoring & Management 2020-12-01
14 Dr. Yeshvandra Verma Biological Monitoring of Exposure to Inorganic Lead in Pregnant Women of Meerut City (Uttar Pradesh), India Journal of ecophysiology and occupational health 2020-04-01
15 Dr. Yeshvandra Verma Distinctive fingerprints of genotoxicity induced by As, Cr, Cd and Ni in a fresh water fish Environmental Sciences and pollution research 2019-05-10
16 Dr. Yeshvandra Verma Renal toxicity of nanoparticles of cadmium sulphide in rat Chemosphere 2018-11-03
17 Dr. Yeshvandra Verma Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat Chemicobiological interactions 2018-11-01
18 Dr. Yeshvandra Verma Biological monitoring of exposure to ambient lead and cadmium through avian feathers: A study from northern India Human and ecological risk assessment 2017-10-09
19 Dr. Yeshvandra Verma Assessment of genotoxicity amongst smokers, alcoholic and tobacco chewers of North India using micronucleus assay and urinary 8hydroxyl-2 deoxyguanosine as biomarker Environmental Monitoring Assessment 2017-07-12
20 Dr. Yeshvandra Verma Biological monitoring of exposure to copper and cadmium in goldsmiths of Meerut City in India International Journal of biological Sciences and Medicine 2016-06-30
21 Dr. Yeshvandra Verma Simultaneous exposure to benzene and alcohol in petrol pump operators International Journal of Pharmaceutical Sciences & research 2016-06-01
22 Dr. Yeshvandra Verma Biological monitoring of exposure to benzene and toluene in tyre retreaders International journal of pharmaceutical sciences and research 2015-07-01
23 Dr. Yeshvandra Verma Assessment of cadmium,chromium and copper levels in market fruit samples in Meerut, North India Toxicological and Environmental Chemistry 2015-05-05
24 Dr. Yeshvandra Verma Influence of testosterone on phase-II enzymes in liver and kidney of benzene-treated rats Toxicological and Environmental Chemistry 2014-12-27
25 Dr. Yeshvandra Verma Hepato-toxicity of benzene in rat after microsomal induction by Phenobarbital Advances in pharmacology and toxicology 2014-04-01
26 Dr. Yeshvandra Verma Modulation of phase-II enzyme activities in benzene treated ovariectomized rats. Environ Toxicol Pharmacol. 2011-05-01
27 Dr. Yeshvandra Verma Endocrinal toxicity of industrial solvents--a mini review Indian Journal of Experimental Biology 2009-07-01
28 Dr. Yeshvandra Verma Modulation of cytochrome P4502E1 and oxidative stress by testosterone in benzene treated rats Indian Journal of Experimental Biology 2008-06-12
29 Dr. Yeshvandra Verma Effect of progesterone on benzene toxicity in rats Archives of Industrial hygiene and toxicology 2008-03-01
30 Dr. Yeshvandra Verma Biological monitoring of inorganic lead with special reference to women - A case study of Indian bangle makers Toxicology International 2007-07-01
31 Dr. Yeshvandra Verma Circadian variation in lipid peroxidation induced by benzene Indian Journal of Experimental Biology 2007-03-01
32 Dr. Yeshvandra Verma Biochemical toxicity of benzene Journal of Environmental Biology 2005-04-01
33 Dr. Yeshvandra Verma Sex differences in oxidative stress induced by benzene in rats Indian Journal of Experimental Biology 2004-01-01
34 Dr. Yeshvandra Verma Biological monitoring of exposure to benzene in traffic policemen of north India Industrial Health, Japan 2003-07-01
35 Dr. Yeshvandra Verma Gender differences in the metabolism of benzene, toluene, trichloroethylene in rats with special reference to certain biochemical parameters. Journal of Environmental Biology 2003-04-01
36 Dr. Yeshvandra Verma Biological monitoring of exposure to toluene in Indian Shoe makers Journal of Ecophysiology and Occupational Health 2002-01-01
37 Dr. Yeshvandra Verma Biological monitoring of exposure to benzene in petrol pump workers and dry cleaners Industrial Health,Japan 2001-10-01

PUBLICATION PROFILE (OTHER THAN RESEARCH PAPERS)

S.No. Name Publication Title Publisher Year of Publication
1 Dr. Satyandra Kumar Chapter in an Edited Books Population Explosion Food Security & Sustainable Development: Issues and Challenges Industrial Chemicals and Heavy Metals: Serious Threats to Food Security 2020-07-20
2 Dr. Yeshvandra Verma Chapter in an Edited Books synthesis and application of nanoparticles Toxicity of Nanomaterials: An Overview 2022-06-21

Achievements

Achievements

Center for Excellence  2021, awarded by Higher Education Department, Government of Uttar Pradesh

Fellowship of Foreign Research Training with Siberian Federal University, Russia awarded by ICMR-DHR, New Delhi to Dr. Yeshvandra Verma.

Fellowship awarded to Varsha Rani (2016-17) Woman Scientist Scheme-C by NASI/DST Delhi

National Fellowship awarded to Meenu Singh(2017-18) UGC New Delhi

Fellowship awarded to Kavita Rana (2018-19) Woman Scientist Scheme-A by Kiran Div./DST Delhi

Fellowship awarded to Huma Khan (2018-19) SRF by ICMR New Delhi

Sakshi Goswami CSIR UGC- JRF 2018 by CSIR, New Delhi

Sumit Rajaura UGC- Forensic Science (NET)  2018 for five years, By UGC New Delhi

Dhvani Yadav UGC- CSIR (Life Science-JRF)  2020 for five years, By CSIR New Delhi

Gaurav Deep UGC- Environmental Science (NET)  2020 for five years, By UGC New Delhi

Lalit Mohan Vashishtha, ICMR fellowship 2022 by ICMR, New Delhi

Time Table

No data available.